Posted by: bescothealthcare | June 21, 2011

New Publication: Assessment of skin autofluorescence as a marker of advanced glycation end product accumulation in type 1 diabetes.

New AGE Reader 2011 Publication

OBJECTIVES:  The aim of the study was to compare AGE accumulation in the skin of patients with type 1 diabetes and nondiabetic population as well as to assess its association with disease duration and metabolic control. We also aimed to assess the potential usefulness of this method in the monitoring of diabetes control, especially in a long-term follow-up.

CONCLUSIONS: AF measurement is a simple and noninvasive method of assessing AGE accumulation in the skin. It may be useful as a secondary method of assessing metabolic control, as it reflects glycemic control over a longer period of time than that reflected by HbA1c levels.

Pol Arch Med Wewn. 2011 Mar;121(3):67-72.


  1. Several studies have shown that tight HbA1c control is necessary but not sufficient to control long-term complications of diabetes. Measurement of skin AGE’s through the AGE Reader is an additional independant risk measure of long-term cardiovascular outcomes, raising the hope that if you can reduce the rate of increase of AGE as we age, then CV complications may be reduced. Using the AGE Reader is thus of benefit even in well controlled people with type 1 diabetes

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